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Anti-Estrogen Inducible Protein pS2 Rabbit pAb (100 μl)
| Reactivity: | M,R & H |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Estrogen Inducible Protein pS2 rabbit polyclonal |
Gene Name: | Trefoil factor 1 |
Synonyms: | Protein pS2, Tff1, Bcei, Breast cancer estrogen inducible protein, HPS2, pNR2 |
Immunogen: | Recombinant protein corresponding to Mouse Estrogen Inducible Protein pS2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 10 kDa |
Observed MW. | 15 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 300-1: 600 | stomach |
IHC | Human | 1: 2200-1: 4400 | stomach |
Background
TFF1 (formerly known as pS2) is a small-secreted protein that belongs to the family of trefoil peptides, and characterized by the presence of one to six cysteine-rich P domains. TFF1 expression is frequently lost in gastric carcinoma, probably through mechanism of DNA methylation, and it is therefore considered as a tumor suppressor gene. The function of TFF1 was first controversially considered as an oncogene in breast cancer.
Images
| Western blot analysis of Myoz2 (GB112739) at dilution of 1: 1000 Lane 1: Mouse heart muscle tissue lysate Lane 2: Mouse skeletal muscle tissue lysate Lane 3: Rat heart muscle tissue lysate Lane 4: Rat skeletal muscle tissue lysate |
 | Immunohistochemistry analysis of paraffin-embedded human stomach using Tff1 (GB112782) at dilution of 1: 4400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |