ABflo® 450 Rabbit anti-Human CD152/CTLA-4 mAb (100 T)

Brand: Abclonal
Cat. #: A26550
Availability: In Stock

$348.00

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Description

Reactivity:	Human
Applications:	FC
Host Species:	Rabbit
Isotype:	IgG
Clonality:	Monoclonal Antibody
Conjugation:	ABflo® 450. Ex:406nm. Em:445nm.
Gene Name:	cytotoxic T-lymphocyte associated protein 4
Gene Symbol:	CTLA4
Synonyms:	CD152; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152
Gene ID:	1493
UniProt ID:	P16410
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 37-162 of human CD152/CTLA-4 (NP_005205.2).
Dilution:	FC,5 μl per 10^6 cells in 100 μl volume
Purification Method:	Affinity purification
Concentration:	0.04 mg/ml
Buffer:	PBS with 0.09% Sodium azide,0.2% BSA, pH7.3.
Storage:	Store at -20°C. Avoid freeze / thaw cycles.
Documents:	Manual-CTLA4 Antibody

Background

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Images

	Flow cytometry: 1×10^6 293F cells (negative control,left) and 293F (Transfection,right) cells were surface-stained with ABflo® 450 Rabbit anti-Human CD152/CTLA-4 mAb (A26550,5 μl/Test,orange line) or ABflo® 450 Rabbit IgG isotype control (5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line).
	Flow cytometry: 1×10^6 293F (Transfection) cells were surface-stained with ABflo® 450 Rabbit IgG isotype control (5 μl/Test,left) or ABflo® 450 Rabbit anti-Human CD152/CTLA-4 mAb (A26550,5 μl/Test,right).