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ABflo® 450 Rabbit anti-Mouse CD11b mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 450. Ex:406nm. Em:445nm. |
| Gene Name: | integrin alpha M |
| Gene Symbol: | Itgam |
| Synonyms: | CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik |
| Gene ID: | 16409 |
| UniProt ID: | P05555 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 143-337 of mouse CD11b (NP_032427.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Itgam antibody |
Background
Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; endocytosis; and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Located in external side of plasma membrane and nucleus. Is integral component of membrane. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; lymphatic vessel; thymus; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).
Images
 | Flow cytometry: 1×10^6 C2C12 cells (negative control,left) and C57BL/6 mouse bone marrow cells (right) were surface-stained with ABflo® 450 Rabbit anti-Mouse CD11b mAb (A26229,5 μl/Test,orange line) or ABflo® 450 Rabbit IgG isotype control (5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 C57BL/6 mouse bone marrow cells were surface-stained with ABflo® 450 Rabbit IgG isotype control (5 μl/Test,left) or ABflo® 450 Rabbit anti-Mouse CD11b mAb (A26229,5 μl/Test,right). |
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