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ABflo® 488 Rabbit anti-Human AXL mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | AXL receptor tyrosine kinase |
| Gene Symbol: | AXL |
| Synonyms: | ARK; UFO; AXL3; JTK11; Tyro7 |
| Gene ID: | 558 |
| UniProt ID: | P30530 |
| Clone ID: | 4F3E2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-449 of human AXL (NP_068713.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-AXL Antibody |
Background
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus.
Images
 | Flow cytometry:1×10^6 Jurkat cells (negative control,left) and U-251 MG cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human AXL mAb(A22502,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 U-251MG cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human AXL mAb(A22502,5 μl/Test,right). |
 | Flow cytometry:1×10^6 Human PBMC cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human AXL mAb(A22502,5 μl/Test,right). |
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