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ABflo® 488 Rabbit anti-Human CD10 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | membrane metalloendopeptidase |
| Gene Symbol: | MME |
| Synonyms: | NEP; SFE; CD10; CALLA; CMT2T; SCA43 |
| Gene ID: | 4311 |
| UniProt ID: | P08473 |
| Clone ID: | 2E1W6 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 52-750 of human CD10 (NP_000893.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-MME Antibody |
Background
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
Images
 | Flow cytometry: 1×10^6 HEL cells (negative control,left) and U-138MG cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human CD10 mAb (A22306,2 μg/mL,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,2 μg/mL,blue line). Non-fluorescently stained cells was used as blank control (red line). |
 | Flow cytometry: 1×10^6 U-138MG cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD10 mAb (A22306,5 μl/Test,right). |
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