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ABflo® 488 Rabbit anti-Human CD105/Endoglin mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | Endoglin |
| Gene Symbol: | ENG |
| Synonyms: | END; HHT1; ORW1 |
| Gene ID: | 2022 |
| UniProt ID: | P17813 |
| Clone ID: | 4O8Z7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-337 of human CD105/Endoglin(NP_001108225.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ENG Antibody |
Background
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry:1×10^6 HAP1 cells (negative control,Left) and HUVEC (Right) were surface-stained with ABflo® 488 Rabbit anti-Human CD105/Endoglin mAb(A24318,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 HUVEC cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-CD105/Endoglin mAb(A24318,5 μl/Test,right). |
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