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ABflo® 488 Rabbit anti-Human CD144/VE Cadherin mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | cadherin 5 |
| Gene Symbol: | CDH5 |
| Synonyms: | 7B4; CD144 |
| Gene ID: | 1003 |
| UniProt ID: | P33151 |
| Clone ID: | 7C7F1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 48-593 of human CD144/VE Cadherin(NP_001786.2) |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CDH5 Antibody |
Background
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer.
Images
 | Flow cytometry:1×10^6 HeLa cells (negative control,Left) and BeWo cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human CD144/VE Cadherin mAb (A23350,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 BeWo cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD144/VE Cadherin mAb (A23350,5 μl/Test,right). |
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