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ABflo® 488 Rabbit anti-Human CD172b mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | signal regulatory protein beta 1 |
| Gene Symbol: | SIRPB1 |
| Synonyms: | CD172b; SIRP-BETA-1 |
| Gene ID: | 10326 |
| UniProt ID: | O00241 |
| Clone ID: | 4H8E3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-371 of human CD172b (NP_006056.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.02 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-SIRPB1 Antibody |
Background
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry: 1×10^6 HEL cells (negative control,left) and U-937 cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human CD172b mAb (A25769,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 U-937 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD172b mAb (A25769,5 μl/Test,right). |
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