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ABflo® 488 Rabbit anti-Human CD239/BCAM mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | basal cell adhesion molecule (Lutheran blood group) |
| Gene Symbol: | BCAM |
| Synonyms: | AU; LU; B-CAM; CD239; MSK19; F8/G253 |
| Gene ID: | 4059 |
| UniProt ID: | P50895 |
| Clone ID: | 6B4O6 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-547 of human CD239/BCAM (NP_005572.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.02 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-BCAM Antibody |
Background
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry: 1×10^6 SH-SY5Y cells(Low Expression,left) and SK-BR-3 cells (right)were surface-stained with ABflo® 488 Rabbit anti-Human CD239/BCAM mAb(A23744,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line).Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 SK-BR-3 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD239/BCAM mAb(A23744,5 μl/Test,right). |
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