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ABflo® 488 Rabbit anti-Human CD305/LAIR1 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | leukocyte associated immunoglobulin like receptor 1 |
| Gene Symbol: | LAIR1 |
| Synonyms: | CD305; LAIR-1 |
| Gene ID: | 3903 |
| UniProt ID: | Q6GTX8 |
| Clone ID: | 6L4P4 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-163 of human CD305/LAIR1(NP_002278.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-LAIR1 Antibody |
Background
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants.
Images
 | Flow cytometry:1×10^6 K-562 cells (negative control,left) and THP-1 cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human CD305/LAIR1 mAb(A23975,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 THP-1 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD305/LAIR1 mAb(A23975,5 μl/Test,right). |
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