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ABflo® 488 Rabbit anti-Human CD97 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | adhesion G protein-coupled receptor E5 |
| Gene Symbol: | ADGRE5 |
| Synonyms: | CD97; TM7LN1 |
| Gene ID: | 976 |
| UniProt ID: | P48960 |
| Clone ID: | 0T1Y2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-398 of human CD97 (NP_510966.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ADGRE5 Antibody |
Background
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.
Images
 | Flow cytometry: 1×10^6 MOLT-4 cells (Low Expression,left) and U-937 cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human CD97 mAb (A22500,2 μg/mL,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,2 μg/mL,blue line). Non-fluorescently stained cells was used as blank control (red line). |
 | Flow cytometry: 1×10^6 U-937 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD97 mAb (A22500,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 MOLT-4 cells (Low Expression) were intracellularly-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD97 mAb (A22500,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with ABflo® 488 Rabbit anti-Human CD97 mAb (A22500,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained Human PBMC was used as blank control (red line). |
 | Flow cytometry: 1×10^6 Human PBMC cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human CD97 mAb (A22500,5 μl/Test,right). |
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