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ABflo® 488 Rabbit anti-Human ErbB3/HER3 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgM |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | erb-b2 receptor tyrosine kinase 3 |
| Gene Symbol: | ERBB3 |
| Synonyms: | HER3; FERLK; LCCS2; VSCN1; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3 |
| Gene ID: | 2065 |
| UniProt ID: | P21860 |
| Clone ID: | 8D6S4 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-643 of human ErbB3/HER3 (NP_001973.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ERBB3 Antibody |
Background
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Images
 | Flow cytometry:1×10^6 Daudi cells (negative control,Left) and MCF7 cells (Right) were surface-stained with ABflo® 488 Rabbit anti-Human ErbB3/HER3 mAb(A24357,5 μl/Test,orange line) or ABflo® 488 Rabbit IgM isotype control (5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 MCF7 cells were surface-stained with ABflo® 488 Rabbit IgM isotype control (5 μl/Test,left) or ABflo® 488 Rabbit anti-Human ErbB3/HER3 mAb(A24357,5 μl/Test,right). |
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