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ABflo® 488 Rabbit anti-Human GSK3β mAb (100 T)
| Reactivity: | Human |
| Applications: | FC (intra) |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | Glycogen synthase kinase 3 beta |
| Gene Symbol: | GSK3B |
| Gene ID: | 2932 |
| UniProt ID: | P49841 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 321-420 of human GSK3β (NP_001139628.1). |
| Dilution: | FC (intra),5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-GSK3B Antibody |
Background
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.
Images
 | Flow cytometry: 1×10^6 knockout (KO) HeLa cells (negative control,left) and HeLa cells (right) were intracellularly-stained with ABflo® 488 Rabbit anti-Human GSK3β mAb (A26725,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 HeLa cells were intracellularly-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human GSK3β mAb (A26725,5 μl/Test,right). |
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