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ABflo® 488 Rabbit anti-Human IL-17RB mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | interleukin 17 receptor B |
| Gene Symbol: | IL17RB |
| Synonyms: | CRL4; EVI27; IL17BR; IL17RH1 |
| Gene ID: | 55540 |
| UniProt ID: | Q9NRM6 |
| Clone ID: | 2T4P2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-289 of human IL-17RB (NP_061195.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-IL17RB antibody |
Background
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.
Images
 | Flow cytometry:1×10^6 MOLT-4 cells (negative control,Left) and HepG2 cells (Right) were surface-stained with ABflo® 488 Rabbit anti-Human IL-17RB mAb(A24315,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
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