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ABflo® 488 Rabbit anti-Human Integrin β5/ITGB5 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | integrin subunit beta 5 |
| Gene Symbol: | ITGB5 |
| Synonyms: | Integrin beta-5 |
| Gene ID: | 3693 |
| UniProt ID: | P18084 |
| Clone ID: | 2B6I4 |
| Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 24-490 of human Integrin β5/ITGB5 (NP_002204.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ITGB5 Antibody |
Background
Ιntegrins, heterodimeric trans-membrane matrix receptors, are mainly involved in the signal transduction and attachments to extra cellular matrix (ECM).†† In ECM they act as a mediator of cell adhesion.† In human, at least 18 α and eight β subunits have been found.† ITGB5 (integrin subunit β 5) helps in facilitation of cancer cell migration, anchorage-independent growth and tumor angiogenesis. Integrin is activated by G-protein-coupled receptors, resulting in the phosphorylation of cytoplasmic domain of the β subunit. The coupled α and β cytoplasmic tails are responsible for maintaining integrin in inactive state.
Images
 | Flow cytometry: 1×10^6 Jurkat cells(negative control,left) and A549 cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human Integrin β5/ITGB5 mAb(A24246,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line).Non-fluorescently stained were used as blank control (red line). |
 | Flow cytometry:1×10^6 A549 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human Integrin β5/ITGB5 mAb(A24246,5 μl/Test,right). |
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