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ABflo® 488 Rabbit anti-Human MICA/MICB mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | MHC class I polypeptide-related sequence B |
| Gene Symbol: | MICB |
| Synonyms: | PERB11.2 |
| Gene ID: | 100507436/4277 |
| UniProt ID: | Q29983/Q29980 |
| Clone ID: | 1A2J8 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-298 of human MICB (NP_005922.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-MICB antibody |
Background
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.
Images
 | Flow cytometry: 1×10^6 SH-SY5Y cells (negative control,left) and K-562 cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human MICA/MICB mAb (A25276,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 K-562 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human MICA/MICB mAb (A25276,5 μl/Test,right). |
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