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ABflo® 488 Rabbit anti-Mouse CD94 mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | killer cell lectin-like receptor, subfamily D, member 1 |
| Gene Symbol: | Klrd1 |
| Synonyms: | CD94 |
| Gene ID: | 16643 |
| UniProt ID: | O54707 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 59-179 of mouse CD94 (NP_034784.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Klrd1 antibody |
Background
CD94 is a 43/39 kD C-type lectin, also known as Kp43. It is present on all NK cells, NKT cells, and a subset of CD8-positive T lymphocytes in most mouse strains. CD94 is a type-II transmembrane protein with an extracellular lectin-like domain and a short cytoplasmic tail. CD94 is expressed as a disulphide-linked heterodimer with a NKG2 subunit believed to mediate signal transduction. When associated with NKG2A, the complex triggers inhibition; when associated with NKG2C, the complex triggers stimulation. The receptor complex of CD94 and NKG2 receptors bind to the ligand, Qa-1, and are thought to play a role in maintaining self-tolerance in developing NK cells.
Images
 | Flow cytometry: 1×10^6 C57BL/6 mouse splenocytes were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Mouse CD94 mAb (A26478,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 C57BL/6 mouse splenocytes were surface-stained with ABflo® 647 Rabbit anti-Mouse CD161c/NK1.1 mAb (5 μl/Test) and ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Mouse CD94 mAb (A26478,5 μl/Test,right). |
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