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ABflo® 488 Rabbit anti-Mouse CD95/FAS mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | Fas cell surface death receptor |
| Gene Symbol: | Fas |
| Synonyms: | lpr; APO1; APT1; CD95; TNFR6; Tnfrsf6 |
| Gene ID: | 14102 |
| UniProt ID: | P25446 |
| Clone ID: | 6A0U7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-169 of mouse CD95/FAS. (NP_032013.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Fas antibody |
Background
CD95, also known as Fas, is a approximately 45 kD type I transmembrane protein in the TNFR superfamily (TNFRSF6). CD95 was expressed in thymus, spleen, liver, heart, lung, ovary and other organs. CD95 binds ligand (FasL) to form a death-inducing signaling complex (DISC) in cells to induce apoptosis. Cd95-induced apoptosis plays an important role in development and in maintaining peripheral tolerance of the immune system.
Images
 | Flow cytometry: 1×10^6 L-929 cells(Low Expression,left) and A20 cells(right) were surface-stained with ABflo® 488 Rabbit anti-Mouse CD95/FAS mAb(A23810,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line).Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 A20 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Mouse CD95/FAS mAb(A23810,5 μl/Test,right). |
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