ABflo® 488 Rabbit anti-Mouse IL1R1/CD121a mAb (100 T)

Brand: Abclonal
Cat. #: A25404
Availability: In Stock

$198.00

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Description

Reactivity:	Mouse
Applications:	FC
Host Species:	Rabbit
Isotype:	IgG
Clonality:	Monoclonal Antibody
Conjugation:	ABflo® 488. Ex:491nm. Em:516nm.
Gene Name:	interleukin 1 receptor, type I
Gene Symbol:	Il1r1
Synonyms:	IL-iR; CD121a; CD121b; IL-1R1; Il1r-1; IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha
Gene ID:	16177
UniProt ID:	P13504
Clone ID:	10C2T5
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-338 of mouse IL1R1/CD121a (NP_032388.1).
Dilution:	FC,5 μl per 10^6 cells in 100 μl volume
Purification Method:	Affinity purification
Concentration:	0.04 mg/mL
Buffer:	PBS with 0.03% proclin300,0.2% BSA, pH7.3.
Storage:	Store at -20°C. Avoid freeze / thaw cycles.
Documents:	Manual-Il1r1 antibody

Background

Enables interleukin-1 binding activity; interleukin-1 receptor activity; and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in brain; dorsal aorta; liver; reproductive system; and spleen. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1).

Images

	Flow cytometry: 1×10^6 Neuro-2a cells (negative control,left) and NIH/3T3 cells (right) were surface-stained with ABflo® 488 Rabbit anti-Mouse IL1R1/CD121a mAb (A25404,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line).
	Flow cytometry: 1×10^6 NIH/3T3 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Mouse IL1R1/CD121a mAb (A25404,5 μl/Test,right).