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ABflo® 594 Rabbit anti-Human CD337/NKp30 mAb (100 T)
| Reactivity: | Human |
| Applications: | IF/ICC, FC (intra) |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | natural cytotoxicity triggering receptor 3 |
| Gene Symbol: | NCR3 |
| Synonyms: | 1C7; MALS; CD337; LY117; NKp30 |
| Gene ID: | 259197 |
| UniProt ID: | O14931 |
| Clone ID: | 3C2E5 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-135 of human CD337/NKp30 (NP_667341.1). |
| Dilution: | IF/ICC,1:50 - 1:200|FC (intra),5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-NCR3 antibody |
Background
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.
Images
 | Confocal imaging of 293T cells transfected with CD337/NKp30 using ABflo® 594 Rabbit anti-Human CD337/NKp30 mAb (A23737, dilution 1:100) (Red). DAPI was used for nuclear staining (Blue). Objective: 100x. |
 | Flow cytometry: 1×10^6 293T cells(Low Expression,left) and 293T(Transfection,right) cells were intracellularly-stained with ABflo® 594 Rabbit anti-Human CD337/NKp30 mAb(A23737,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (5 μl/Test,blue line).Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 293T(Transfection) cells were intracellularly-stained with ABflo® 594 Rabbit IgG isotype control (5 μl/Test,left) or ABflo® 594 Rabbit anti-Human CD337/NKp30 mAb(A23737,5 μl/Test,right). |
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