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ABflo® 594 Rabbit anti-Human CD35 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | complement C3b/C4b receptor 1 (Knops blood group) |
| Gene Symbol: | CR1 |
| Synonyms: | KN; C3BR; C4BR; CD35 |
| Gene ID: | 1378 |
| UniProt ID: | P17927 |
| Clone ID: | 9Q5N6 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 901-1095 of human CD35 (NP_000564.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CR1 Antibody |
Background
Complement receptor type 1 (CR1/CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells, neutrophils, monocytes, and renal podocytes. As a component of the host's innate immune system, CR1/CD35 expressed on neutrophils and monocytes binds to ligands coated with complement opsonins C3b and C4b, thereby promoting phagocytosis and pro-inflammatory cytokine production. CR1/CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b.
Images
 | Flow cytometry: 1×10^6 REH cells (negative control,left) and Human PBMC (right) were surface-stained with ABflo® 594 Rabbit anti-Human CD35 mAb(A24699,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human CD35 mAb (A24699,5 μl/Test,right). |
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