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ABflo® 594 Rabbit anti-Human CD38 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | CD38 molecule |
| Gene Symbol: | CD38 |
| Synonyms: | ADPRC1; cADPR1; ADPRC 1 |
| Gene ID: | 952 |
| UniProt ID: | P28907 |
| Clone ID: | 8E6Q6 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 43-300 of human CD38 (NP_001766.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CD38 Antibody |
Background
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
Images
 | Flow cytometry: 1×10^6 Hep G2 cells (negative control,left) and Daudi cells (right) were surface-stained with ABflo® 594 Rabbit anti-Human CD38 mAb (A25486,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Daudi cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human CD38 mAb (A25486,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with ABflo® 594 Rabbit anti-Human CD38 mAb (A25486,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained Human PBMC were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human CD38 mAb (A25486,5 μl/Test,right). |
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