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ABflo® 594 Rabbit anti-Human FAP mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | fibroblast activation protein alpha |
| Gene Symbol: | FAP |
| Synonyms: | FAPA; SIMP; DPPIV; FAPalpha |
| Gene ID: | 2191 |
| UniProt ID: | Q12884 |
| Clone ID: | 2I9D4 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-760 of human FAP (NP_004451.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-FAP Antibody |
Background
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry: 1×10^6 Jurkat cells (negative control,left) and U-87MG cells (right) were surface-stained with ABflo® 594 Rabbit anti-Human FAP mAb (A24967,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 U-87MG cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human FAP mAb (A24967,5 μl/Test,right). |
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