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ABflo® 594 Rabbit anti-Human IL-1β mAb (100 T)
| Reactivity: | Human |
| Applications: | FC (intra) |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | Interleukin 1 beta |
| Gene Symbol: | IL1B |
| Synonyms: | IL-1; IL1F2; IL1beta; IL1-BETA |
| Gene ID: | 3553 |
| UniProt ID: | P01584 |
| Clone ID: | 2P0E5 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 117-269 of human IL1β (NP_000567.1). |
| Dilution: | FC (intra),5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-IL1B Antibody |
Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Images
 | Flow cytometry: 1×10^6 293T cells(negative control,left) and 293T (Transfection,right) were intracellularly-stained with ABflo® 594 Rabbit anti-Human IL-1β mAb(A24245,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line).Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 293T(Transfection) cells were intracellularly-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human IL-1β mAb(A24245,5 μl/Test,right). |
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