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ABflo® 594 Rabbit anti-Human KIR2DL2/KIR2DL3 mAb (100 T)
| Reactivity: | Human |
| Applications: | IF/ICC, FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 |
| Gene Symbol: | KIR2DL2 |
| Synonyms: | NKAT6; p58.2; CD158b; NKAT-6; CD158B1 |
| Gene ID: | 3803/3804 |
| UniProt ID: | P43628 |
| Clone ID: | 7A7M7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-245 of human KIR2DL3(NP_056952.2). |
| Dilution: | IF/ICC,1:50 - 1:200|FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-KIR2DL2 antibody |
Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Images
 | Confocal imaging of 293F cells transfected with KIR2DL2/KIR2DL3 using ABflo® 594 Rabbit anti-Human KIR2DL2/KIR2DL3 mAb (A24576, dilution 1:50). DAPI was used for nuclear staining (Blue). Objective: 100x. |
 | Flow cytometry:1×10^6 293F cells (negative control,left) and 293F(Transfection,right) cells were surface-stained with ABflo® 594 Rabbit anti-Human KIR2DL2/KIR2DL3 mAb(A24576,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 293F(Transfection) cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human KIR2DL2/KIR2DL3 mAb(A24576,5 μl/Test,right). |
 | Flow cytometry:1×10^6 CHO cells (negative control,left) and CHO(Transfection,right) cells were surface-stained with ABflo® 594 Rabbit anti-Human KIR2DL2/KIR2DL3 mAb(A24576,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 CHO(Transfection) cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human KIR2DL2/KIR2DL3 mAb(A24576,5 μl/Test,right). |
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