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ABflo® 647 Rabbit anti-Human CD11a mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | integrin subunit alpha L |
| Gene Symbol: | ITGAL |
| Synonyms: | CD11A; LFA-1; LFA1A |
| Gene ID: | 3683 |
| UniProt ID: | P20701 |
| Clone ID: | 1D7Z3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-340 of human CD11a (NP_002200.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ITGAL Antibody |
Background
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry: 1×10^6 K-562 cells (negative control,left) and THP-1 cells (right) were surface-stained with ABflo® 647 Rabbit anti-Human CD11a mAb (A24898,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 THP-1 cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human CD11a mAb (A24898,5 μl/Test,right). |
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