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ABflo® 647 Rabbit anti-Human CD177 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | CD177 molecule |
| Gene Symbol: | CD177 |
| Synonyms: | NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP |
| Gene ID: | 57126 |
| UniProt ID: | Q8N6Q3 |
| Clone ID: | 6U8P4 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-407 of human CD177(NP_065139.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CD177 antibody |
Background
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified.
Images
 | Flow cytometry:1×10^6 RPMI-8226 cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human CD177 mAb(A24402,5 μl/Test,right). |
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