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ABflo® 647 Rabbit anti-Human TrkA mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | neurotrophic receptor tyrosine kinase 1 |
| Gene Symbol: | NTRK1 |
| Synonyms: | MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA |
| Gene ID: | 4914 |
| UniProt ID: | P04629 |
| Clone ID: | 5J9T5 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-407 of human TrkA (NP_002520.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-NTRK1 Antibody |
Background
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Images
 | Flow cytometry:1×10^6 MOLT-4 cells (negative control,left) and SH-SY5Y cells (right) were surface-stained with TrkA Rabbit mAb(A23974,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line),followed by Alexa Fluor® 647 conjugated goat anti-rabbit pAb (1:200 dilution) staining. Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 SH-SY5Y cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human TrkA mAb(A23974,5 μl/Test,right). |
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