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ABflo® 647 Rabbit anti-Human VEGFR2/CD309 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | kinase insert domain receptor |
| Gene Symbol: | KDR |
| Synonyms: | FLK1; CD309; VEGFR; VEGFR2 |
| Gene ID: | 3791 |
| UniProt ID: | P35968 |
| Clone ID: | 7Q8C9 |
| Immunogen: | Recombinant protein of human VEGFR2/CD309. |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-KDR Antibody |
Background
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Images
 | Flow cytometry:1×10^6 293F cells (negative control,Left) and 293F(Transfection,right) cells were surface-stained with ABflo® 647 Rabbit anti-Human VEGFR2/CD309 mAb(A23357,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 293F(Transfection) cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human VEGFR2/CD309 mAb(A23357,5 μl/Test,right). |
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