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ABflo® 700 Rabbit anti-Human CD304/Neuropilin-1 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 700. Ex:690nm. Em:713nm. |
| Gene Name: | neuropilin 1 |
| Gene Symbol: | NRP1 |
| Synonyms: | NP1; NRP; BDCA4; CD304; VEGF165R |
| Gene ID: | 8829 |
| UniProt ID: | O14786 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-644 of human CD304/Neuropilin-1 (NP_003864.5). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-NRP1 Antibody |
Background
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells.
Images
 | Flow cytometry: 1×10^6 K-562 cells (negative control,left) and A549 cells (right) were surface-stained with ABflo® 700 Rabbit anti-Human CD304/Neuropilin-1 mAb (A26479,5 μl/Test,orange line) or ABflo® 700 Rabbit IgG isotype control (A25976,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 A549 cells were surface-stained with ABflo® 700 Rabbit IgG isotype control (A25976,5 μl/Test,left) or ABflo® 700 Rabbit anti-Human CD304/Neuropilin-1 mAb (A26479,5 μl/Test,right). |
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