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APC/Cyanine7 Rabbit anti-Human CD3E mAb (100 T)
| Reactivity: | Human |
| Applications: | FC (intra) |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | APC-Cy7. Ex:651nm. Em:779nm. |
| Gene Name: | CD3 epsilon subunit of T-cell receptor complex |
| Gene Symbol: | CD3E |
| Synonyms: | T3E; TCRE; IMD18; CD3epsilon |
| Gene ID: | 916 |
| UniProt ID: | P07766 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CD3E (NP_000724.1). |
| Dilution: | FC (intra),5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CD3E Antibody |
Background
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Images
 | Flow cytometry: 1×10^6 PC-3 cells (negative control,left) and Human PBMC (right) were intracellularly-stained with APC/Cyanine7 Rabbit anti-Human CD3E mAb (A27405,5 μl/Test,orange line) or APC/Cyanine7 Rabbit IgG isotype control (5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
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