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APC Rabbit anti-Human CD209/DC-SIGN mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | APC. Ex:650nm. Em:660nm. |
| Gene Name: | CD209 molecule |
| Gene Symbol: | CD209 |
| Synonyms: | CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; hDC-SIGN |
| Gene ID: | 30835 |
| UniProt ID: | Q9NNX6 |
| Clone ID: | 10M9V7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 59-404 of human CD209/DC-SIGN (NP_066978.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CD209 antibody |
Background
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity.
Images
 | Flow cytometry: 1×10^6 293F cells(negative control,left) and THP-1 cells(right) were surface-stained with APC Rabbit anti-Human CD209/DC-SIGN mAb(A23594,5 μl/Test,orange line) or APC Rabbit IgG isotype control (5 μl/Test,blue line).Non-fluorescently stained cells was used as blank control (red line). |
 | Flow cytometry:1×10^6 THP-1 cells were surface-stained with APC Rabbit IgG isotype control (5 μl/Test,left) or APC Rabbit anti-Human CD209/DC-SIGN mAb(A23594,5 μl/Test,right). |
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