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APC Rabbit anti-Human Glypican 3 (GPC3) mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | APC. Ex:650nm. Em:660nm. |
| Gene Name: | glypican 3 |
| Gene Symbol: | GPC3 |
| Synonyms: | SGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2 |
| Gene ID: | 2719 |
| UniProt ID: | P51654 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 481-580 of human Glypican 3 (GPC3) (NP_004475.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-GPC3 Antibody |
Background
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
Images
 | Flow cytometry: 1×10^6 K-562 cells (negative control,left) and Hep G2 cells (right) were surface-stained with APC Rabbit anti-Human Glypican 3 (GPC3) mAb (A26131,5 μl/Test,orange line) or APC Rabbit IgG isotype control (A24173,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Hep G2 cells were surface-stained with APC Rabbit IgG isotype control (A24173,5 μl/Test,left) or APC Rabbit anti-Human Glypican 3 (GPC3) mAb (A26131,5 μl/Test,right). |
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