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APC Rabbit anti-Human LGR5 (GPR49) mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | APC. Ex:650nm. Em:660nm. |
| Gene Name: | leucine rich repeat containing G protein-coupled receptor 5 |
| Gene Symbol: | LGR5 |
| Synonyms: | FEX; HG38; GPR49; GPR67; GRP49 |
| Gene ID: | 8549 |
| UniProt ID: | O75473 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 480-580 of human LGR5 (NP_003658.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-LGR5 Antibody |
Background
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry: 1×10^6 U-937 cells (negative control,left) and Hep G2 cells (right) were surface-stained with APC Rabbit anti-Human LGR5 (GPR49) mAb (A26864,5 μl/Test,orange line) or APC Rabbit IgG isotype control (A24173,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Hep G2 cells were surface-stained with APC Rabbit IgG isotype control (A24173,5 μl/Test,left) or APC Rabbit anti-Human LGR5 (GPR49) mAb (A26864,5 μl/Test,right). |
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