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APC Rabbit anti-Human Nectin-1/CD111 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | APC. Ex:650nm. Em:660nm. |
| Gene Name: | nectin cell adhesion molecule 1 |
| Gene Symbol: | NECTIN1 |
| Synonyms: | ED4; PRR; HIgR; HV1S; HVEC; OFC7; PRR1; PVRR; CD111; PVRL1; PVRR1; SK-12; CLPED1; nectin-1 |
| Gene ID: | 5818 |
| UniProt ID: | Q15223 |
| Clone ID: | 5D2S1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human Nectin-1/CD111 (NP_002846.3). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-NECTIN1 Antibody |
Background
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
Images
 | Flow cytometry: 1×10^6 K-562 cells (negative control,left) and SH-SY5Y cells (right) were surface-stained with APC Rabbit anti-Human Nectin-1/CD111 mAb (A25197,2 μg/mL,orange line) or APC Rabbit IgG isotype control (A24173,5 μl/Test,blue line), followed by APC conjugated goat anti-Rabbit pAb staining. Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 SH-SY5Y cells were surface-stained with APC Rabbit IgG isotype control (A24173,5 μl/Test,left) or APC Rabbit anti-Human Nectin-1/CD111 mAb (A25197,5 μl/Test,right). |
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