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PE Rabbit anti-Human CD197/CCR7 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | C-C motif chemokine receptor 7 |
| Gene Symbol: | CCR7 |
| Synonyms: | BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7 |
| Gene ID: | 1236 |
| UniProt ID: | P32248 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-59 of human CD197/CCR7 (NP_001829.1). |
| Dilution: | FC, 5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CCR7 Antibody |
Background
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
Images
 | Flow cytometry: 1×10^6 293T cells (negative control,left) and 293T (Transfection,right) cells were surface-stained with PE Rabbit anti-Human CD197/CCR7 mAb (A26833,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 293T (Transfection) cells were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human CD197/CCR7 mAb (A26833,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with ABflo® 488 Mouse anti-Human CD3 (A25188,5 μl/Test) and PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human CD197/CCR7 mAb (A26833,5 μl/Test,right). Cells in the lymphocyte gate were used for analysis. |
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