PE Rabbit anti-Human CD42b mAb (100 T)

Background

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.

Images

	Flow cytometry:1×10^6 HAP1 cells (negative control,left) and HEL cells (right) were surface-stained with PE Rabbit anti-Human CD42b mAb(A24594,5 μl/Test,orange line) or PE Rabbit IgG isotype control (5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line).
	Flow cytometry:1×10^6 HEL cells cells were surface-stained with PE Rabbit IgG isotype control (5 μl/Test,left) or PE Rabbit anti-Human CD42b mAb(A24594,5 μl/Test,right).

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