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PE Rabbit anti-Human HIF-1 alpha mAb (100 T)
| Reactivity: | Human |
| Applications: | FC (intra) |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | Hypoxia inducible factor 1 subunit alpha |
| Gene Symbol: | HIF1A |
| Synonyms: | HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha |
| Gene ID: | 3091 |
| UniProt ID: | Q16665 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 401-500 of HIF1 alpha (NP_001521.1). |
| Dilution: | FC (intra),5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-HIF1A Antibody |
Background
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Images
 | Flow cytometry:1×10^6 HeLa cells (untreated,left) and HeLa cells (treated with Deferoxamine,right) were intracellularly-stained with PE Rabbit anti-Human HIF-1 alpha mAb (A27280,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 HeLa cells (untreated,left) and HeLa cells (treated with Deferoxamine,right) were intracellularly-stained with PE Rabbit anti-Human HIF-1 alpha mAb (A27280,5 μl/Test). |
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