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PE Rabbit anti-Mouse IL1R1/CD121a mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | interleukin 1 receptor, type I |
| Gene Symbol: | Il1r1 |
| Synonyms: | IL-iR; CD121a; CD121b; IL-1R1; Il1r-1; IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha |
| Gene ID: | 16177 |
| UniProt ID: | P13504 |
| Clone ID: | 3S5W9 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-338 of mouse IL1R1/CD121a (NP_032388.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Il1r1 antibody |
Background
Enables interleukin-1 binding activity; interleukin-1 receptor activity; and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in brain; dorsal aorta; liver; reproductive system; and spleen. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1).
Images
 | Flow cytometry: 1×10^6 Neuro-2a cells (negative control,left) and NIH/3T3 cells (right) were surface-stained with PE Rabbit anti-Mouse IL1R1/CD121a mAb (A25858,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 NIH/3T3 cells were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Mouse IL1R1/CD121a mAb (A25858,5 μl/Test,right). |
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