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PerCP Rabbit anti-Human CD45 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PerCP. Ex:482nm. Em:678nm. |
| Gene Name: | protein tyrosine phosphatase receptor type C |
| Gene Symbol: | PTPRC |
| Synonyms: | LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105 |
| Gene ID: | 5788 |
| UniProt ID: | P08575 |
| Clone ID: | 3R8G4 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-577 of human CD45 (P08575). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-PTPRC Antibody |
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Images
 | Flow cytometry: 1×10^6 293T cells (negative control,left) and Jurkat cells (right) were surface-stained with PerCP Rabbit anti-Human CD45 mAb (A25624,5 μl/Test,orange line) or PerCP Rabbit IgG isotype control (A24204,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Jurkat cells were surface-stained with PerCP Rabbit IgG isotype control (A24204,5 μl/Test,left) or PerCP Rabbit anti-Human CD45 mAb (A25624,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with PerCP Rabbit anti-Human CD45 mAb (A25624,5 μl/Test,orange line) or PerCP Rabbit IgG isotype control (5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). Cells in the lymphocyte gate were used for analysis. |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with PerCP Rabbit IgG isotype control (5 μl/Test,left) or PerCP Rabbit anti-Human CD45 mAb (A25624,5 μl/Test,right). Cells in the lymphocyte gate were used for analysis. |
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