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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Growth factor receptor-bound protein 7 |
Synonyms: | B47, GRB7, GRB7 adapter protein |
Immunogen: | Recombinant protein corresponding to Mouse GRB7 |
Uniprot ID: | Q03160 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Product Usage Information
IHC/IF | Human | 1: 500-1: 1000 | colon cancer, esophageal cancer, gastric cancer |
Background
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration (By similarity). Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated.
Images
| Immunohistochemistry analysis of paraffin embedded human colon cancer using GRB7 (GB114497) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human esophageal cancer using GRB7 (GB114497) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human gastric cancer using GRB7 (GB114497) at dilution of 1: 500 |
| Immunofluorescence analysis of paraffin embedded human breast cancer using GRB7 (GB114497) at dilution of 1: 500 |
| Immunofluorescence analysis of paraffin embedded human colon cancer using GRB7 (GB114497) at dilution of 1: 500 |
| Immunofluorescence analysis of paraffin embedded human esophageal carcinoma using GRB7 (GB114497) at dilution of 1: 500 |
| Immunofluorescence analysis of paraffin embedded human liver cancer using GRB7 (GB114497) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |