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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, IF/IC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | glutamate ionotropic receptor AMPA type subunit 3 |
| Gene Symbol: | GRIA3 |
| Synonyms: | GLUR3; GLURC; GluA3; MRX94; MRXSW; GLUR-C; iGluR3; GLUR-K3; GRIA3 |
| Gene ID: | 2892 |
| UniProt ID: | P42263 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-490 of human GRIA3 (NP_000819.3). |
| Dilution: | WB 1:500-1:1000; IF/IC 1:50-1:100 |
| Purification Method: | Affinity purification |
| Concentration: | 0.36 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-GRIA3 antibody |
Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
Images
 | Western blot analysis of various lysates using GRIA3 Rabbit pAb (A13993) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunofluorescence analysis of HeLa cells using GRIA3 Rabbit pAb (A13993). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining. |
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