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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Inhibitor of growth protein 5 |
Synonyms: | ING5, Inhibitor of growth protein 5, p28ING5 |
Immunogen: | Recombinant protein corresponding to Mouse ING5 |
Uniprot ID: | Q9D8Y8 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 28 kDa / 34 kDa |
Product Usage Information
WB | Mouse | 1: 1000-1: 2000 | kidney |
Background
ING5, also named as p28ING5, belongs to the ING family. It is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. ING5 is a component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. (PMID:12750254) Altered ING5 expression and its shift into the cytoplasm may have an impact on the malignant transformation of colorectal epithelial cells and should be considered as a biomarker for colorectal carcinogenesis.
Images
| Western blot analysis of ING5 (GB114148) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |