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| Reactivity: | Human, Mouse |
| Applications: | WB, IP, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | IRF5 interferon regulatory factor 5 |
| Gene Symbol: | IRF5 |
| Synonyms: | SLEB10; IRF5 |
| Gene ID: | 3663 |
| UniProt ID: | Q13568 |
| Clone ID: | 6L2B5 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 6-151 of human IRF5 (Q13568). |
| Dilution: | WB 1:1000-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 1.2 mg/mL |
| Buffer: | PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-IRF5 antibody |
Background
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
Images
 | Western blot analysis of various lysates using IRF5 Rabbit mAb (A11106) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |
 | Immunoprecipitation analysis of 600 μg extracts of Mouse thymus using 3 μg IRF5 antibody (A11106). Western blot was performed from the immunoprecipitate using IRF5 antibody (A11106) at a dilution of 1:500. |
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