JAK3 Rabbit pAb (20 μl)

JAK3 Rabbit pAb (20 μl)

Brand: Abclonal
Cat. #: A0748
Availability: In Stock
$108.00
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Reactivity: Human    
Applications: WB, IF/IC, ELISA    
Host Species: Rabbit    
Isotype: IgG    
Clonality: Polyclonal antibody    
Gene Name: Janus kinase 3
Gene Symbol: JAK3
Synonyms: JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; JAK3
Gene ID: 3718
UniProt ID: P52333
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 350-530 of JAK3 (NP_000206.2).
Dilution: WB 1:1000-1:5000; IF/IC 1:50-1:200
Purification Method: Affinity purification
Concentration: 2.13 mg/mL
Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Documents: Manual-JAK3 antibody




Background

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).




Images

JAK3 antibodyWestern blot analysis of various lysates, using JAK3 Rabbit pAb (A0748) at 1:2000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit (RM00021).
Exposure time: 60s.
Immunofluorescence analysis of TF-1 cells using JAK3 Rabbit pAb (A0748) at dilution of 1:50 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining.



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