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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | cyclin dependent kinase 2 |
| Gene Symbol: | CDK2 |
| Synonyms: | CDKN2; p33(CDK2) |
| Gene ID: | 1017 |
| UniProt ID: | P24941 |
| Clone ID: | 24GB4315 |
| Immunogen: | A synthesized peptide derived from human Cdk2 |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene CDK2 encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants.
Images
 | Western blotting analysis using anti-cyclin dependent kinase 2 antibody (Cat#63162). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-cyclin dependent kinase 2 antibody (Cat#63162, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-cyclin dependent kinase 2 antibody (Cat#63162). Cyclin dependent kinase 2 expression in wild type (WT) and cyclin dependent kinase 2 (CDK2) shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. β-Tubulin serves as a loading control. The blot was incubated with anti-cyclin dependent kinase 2 antibody (Cat#63162, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of cyclin dependent kinase 2 expression in HepG2 cells using anti-cyclin dependent kinase 2 antibody (Cat#63162, 1:2,000). Green, isotype control; red, cyclin dependent kinase 2. |
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