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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | casein kinase 1 alpha 1 |
| Gene Symbol: | CSNK1A1 |
| Synonyms: | CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p |
| Gene ID: | 1452 |
| UniProt ID: | P48729 |
| Clone ID: | 25GB125 |
| Immunogen: | A synthesized peptide derived from human Casein Kinase 1 alpha |
| Dilution: | WB 1:1,000-1:5,000; FC 1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
Enables protein serine/threonine kinase activity. Involved in several processes, including peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of signal transduction. Located in cytoskeleton; cytosol; and nucleus. Part of beta-catenin destruction complex. Biomarker of Alzheimer's disease and inclusion body myositis.
Images
 | Western blotting analysis using anti-CSNK1A1 antibody (Cat#65200). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-CSNK1A1 antibody (Cat#65200, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Western blotting analysis using anti-CSNK1A1 antibody (Cat#65200). CSNK1A1 expression in wild-type (WT) and CSNK1A1 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-CSNK1A1 antibody (Cat#65200, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of CSNK1A1 expression in C2C12 cells using anti-CSNK1A1 antibody (Cat#65200, 1:2,000). Green, isotype control; red, CSNK1A1. |
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