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| Reactivity: | Human |
| Applications: | WB, FC |
| Host Species: | Mouse |
| Isotype: | IgG1 |
| Clonality: | Monoclonal antibody |
| Gene Name: | dynein cytoplasmic 1 light intermediate chain 1 |
| Gene Symbol: | DYNC1LI1 |
| Synonyms: | LIC1; DLC-A; DLIC-1; DNCLI1 |
| Gene ID: | 51143 |
| UniProt ID: | Q9Y6G9 |
| Clone ID: | 24GB8110 |
| Immunogen: | Recombinant protein of human DYNC1LI1 |
| Dilution: | WB 1:500-1:2,500; FC 1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking.
Images
 | Western blotting analysis using anti-DYNC1LI1 antibody (Cat#63836). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-DYNC1LI1 antibody (Cat#63836, 1:2,500) and HRP-conjugated goat anti-mouse secondary antibody (Cat#101, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-DYNC1LI1 antibody (Cat#63836). DYNC1LI1 expression in wild-type (WT) and DYNC1LI1 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-DYNC1LI1 antibody (Cat#63836, 1:2,500) and HRP-conjugated goat anti-mouse secondary antibody (Cat#101, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Flow cytometric analysis of DYNC1LI1 expression in HepG2 cells using anti-DYNC1LI1 antibody (Cat#63836, 1:1,000). Green, isotype control; red, DYNC1LI1. |
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