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| Reactivity: | Human |
| Applications: | WB |
| Host Species: | Mouse |
| Isotype: | IgG2b |
| Clonality: | Monoclonal antibody |
| Gene Name: | farnesyl-diphosphate farnesyltransferase 1 |
| Gene Symbol: | FDFT1 |
| Synonyms: | SS; SQS; DGPT; ERG9; SQSD |
| Gene ID: | 2222 |
| UniProt ID: | P37268 |
| Clone ID: | 24GB5645 |
| Immunogen: | Recombinant protein of human FDFT1 |
| Dilution: | WB 1:2,500-1:5,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene FDFT1 encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
Images
 | Western blotting analysis using anti-farnesyl-diphosphate farnesyltransferase 1 antibody (Cat#63442). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-farnesyl-diphosphate farnesyltransferase 1 antibody (Cat#63442, 1:5,000) and HRP-conjugated goat anti-mouse secondary antibody (Cat#101, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit(Cat#716). |
 | Western blotting analysis using anti-farnesyl-diphosphate farnesyltransferase 1 antibody (Cat#63442). Farnesyl-diphosphate farnesyltransferase 1 expression in wild type (WT) and farnesyl-diphosphate farnesyltransferase 1 (FDFT1) shRNA knockdown (KD) HT-1080 cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-farnesyl-diphosphate farnesyltransferase 1 antibody (Cat#63442, 1:5,000) and HRP-conjugated goat anti-mouse secondary antibody (Cat#101, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
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