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| Reactivity: | Human, Rat |
| Applications: | WB, FC |
| Host Species: | Mouse |
| Isotype: | IgG1 |
| Clonality: | Monoclonal antibody |
| Gene Name: | latexin |
| Gene Symbol: | LXN |
| Synonyms: | ECI; TCI |
| Gene ID: | 56925 |
| UniProt ID: | Q9BS40 |
| Clone ID: | 24GB6370 |
| Immunogen: | Recombinant protein of human LXN |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. The encoded protein, latexin, downregulates the population size of hematopoietic stem cells. This protein is found to be downregulated in cancer cells because of promoter hypermethylation.
Images
 | Western blotting analysis using anti-latexin antibody (Cat#63529). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-latexin antibody (Cat#63529, 1:5,000) and HRP-conjugated goat anti-mouse secondary antibody (Cat#101, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Western blotting analysis using anti-latexin antibody (Cat#63529). Latexin expression in wild type (WT) and latexin (LXN) shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-latexin antibody (Cat#63529, 1:5,000) and HRP-conjugated goat anti-mouse secondary antibody (Cat#101, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Flow cytometric analysis of Latexin expression in HepG2 cells using anti-Latexin antibody (Cat#63529, 1:2,000). Green, isotype control; red, Latexin. |
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